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data-elementor-type="product" data-elementor-id="427888" class="elementor elementor-427888 elementor-location-single post-434266 product type-product status-publish has-post-thumbnail product_cat-recombinant first instock taxable shipping-taxable purchasable product-type-simple catalog-layout-default product-images-columns-medium product-images-align-left product" data-elementor-settings="[]">


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Recombinant 2019-nCoV coronavirus Spike protein S1 subunit receptor binding domain


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$855.00


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Cat Number Spike-19V Category
sars-cov-2-recombinant

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Description

Recombinant COVID-19 (2019 novel coronavirus) Spike protein S1 subunit receptor binding domain (RBD) was fused to Mouse IgG1 Fc tag at C-terminus and expressed in human cells. The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell: they are essential for both host specificity and viral infectivity. The term ‘peplomer’ is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.

Additional information

Weight 0.5 kg

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